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Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Engineering doi: 10.1016/j.eng.2023.09.017

Abstract: A comprehensive efficacy assessment system that bridges the gap between TCM and modern medical terminologyComprehensive preclinical efficacy evaluations have demonstrated the equivalence of the therapeutic effectsFurthermore, preclinical toxicological assessment and phase Ⅰ clinical trials show that the safety of

Keywords： Artificial bear bile     Chemical profile     Formula optimization     Pharmacodynamic consistency     Preclinical toxicologicalassessment    

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Two-dimensional numerical and eco-toxicological modeling of chemical spills

Suiliang HUANG, Yafei JIA, Sam S. Y. WANG

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 178-185 doi: 10.1007/s11783-009-0020-9

Abstract: Based on a review of three types of current eco-toxicological models of chemicals, i.e., ACQUATOX modelCBR) model and dynamic energy budget (DEBtox) model, this paper presents an uncoupled numerical eco-toxicological

Keywords： chemical spills     acute effects     aquatic ecosystem     eco-toxicological modeling    

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The Application and the Developing Direction of Forensic Toxicological Analysis

Liu Yao

Strategic Study of CAE 2002, Volume 4, Issue 9,   Pages 42-44

Abstract:

This article introduces two cases, in which the result of toxicological analysis provides the importantclue to investigator and the evidence to the justice for one case, while the result of toxicologicalThe article introduces two problems of toxicological analysis during the extraction.The article thinks that the present level of toxicological analysis for some techniques in China is nearIn the future, the development of toxicological analysis should be in accordance with domestic reguirement

Keywords： forensic toxicological analysis     standard management     extraction from biological material    

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human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like cells: a preclinical

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Frontiers of Medicine 2013, Volume 7, Issue 3,   Pages 345-353 doi: 10.1007/s11684-013-0282-2

Abstract:

Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) possess various advantageous properties, including self-renewal, extended proliferation potential, multi-lineage differentiation potential and capacity for differentiating into sweat gland-like cells in certain conditions. However, little is known about the effect of clinical-grade culture conditions on these properties and on the differentiative potential of hUC-MSCs. In this study, we sought to investigate the properties of hUC-MSCs expanded with animal serum free culture media (ASFCM) in order to determine their potential for differentiation into sweat gland-like cells. We found that primary cultures of hUC-MSCs could be established with ASFCM. Moreover, cells cultured in ASFCM showed vigorous proliferation comparable to those of cells grown in classical culture conditions containing fetal bovine serum (FBS). Morphology of hUC-MSCs cultured in ASFCM was comparable to those of cells grown under classical culture conditions, and hUC-MSCs grown in both of the two culture conditions tested showed the typical antigen profile of MSCs—positive for CD29, CD44, CD90, and CD105, and negative for CD34 and CD45, as expected. Chromosomal aberration assay revealed that the cells were stable after long-term culture under both culture conditions. Like normal cultured MSCs, hUC-MSCs induced under ASFCM conditions exhibited expression of the same markers (CEA, CK14 and CK19) and developmental genes (EDA and EDAR) that are characteristic of normal sweat gland cells. Taken together, our findings indicate that the classical culture medium used to differentiate hUC-MSCs into sweat gland-like cells can be replaced safely by ASFCM for clinical purposes.

Keywords： umbilical cord     mesenchymal stem cells     sweat gland     preclinical    

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non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical

Frontiers of Medicine doi: 10.1007/s11684-023-0996-8

Abstract: OX40 is a costimulatory receptor that is expressed primarily on activated CD4+, CD8+, and regulatory T cells. The ligation of OX40 to its sole ligand OX40L potentiates T cell expansion, differentiation, and activation and also promotes dendritic cells to mature to enhance their cytokine production. Therefore, the use of agonistic anti-OX40 antibodies for cancer immunotherapy has gained great interest. However, most of the agonistic anti-OX40 antibodies in the clinic are OX40L-competitive and show limited efficacy. Here, we discovered that BGB-A445, a non-ligand-competitive agonistic anti-OX40 antibody currently under clinical investigation, induced optimal T cell activation without impairing dendritic cell function. In addition, BGB-A445 dose-dependently and significantly depleted regulatory T cells in vitro and in vivo via antibody-dependent cellular cytotoxicity. In the MC38 syngeneic model established in humanized OX40 knock-in mice, BGB-A445 demonstrated robust and dose-dependent antitumor efficacy, whereas the ligand-competitive anti-OX40 antibody showed antitumor efficacy characterized by a hook effect. Furthermore, BGB-A445 demonstrated a strong combination antitumor effect with an anti-PD-1 antibody. Taken together, our findings show that BGB-A445, which does not block OX40–OX40L interaction in contrast to clinical-stage anti-OX40 antibodies, shows superior immune-stimulating effects and antitumor efficacy and thus warrants further clinical investigation.

Keywords： BGB-A445     OX40     agonistic antibody     OX40L noncompetitive    

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Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Frontiers of Medicine 2016, Volume 10, Issue 1,   Pages 104-110 doi: 10.1007/s11684-016-0432-4

Abstract: Sophisticated preclinical models that fully represent intra- and inter-tumoral heterogeneity are requiredretain the histological and genetic features of their donor tumors have been shown to be the preferred preclinicaltool in translational cancer research compared with other conventional preclinical models.In this paper, we discuss the establishment, characterization, and preclinical applications of the PDXAlthough various limitations still exist, this preclinical approach should be further tested and improved

Keywords： patient-derived xenograft models     personalized medicine     co-clinical trial     patient stratification     oral squamous cell carcinoma    

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Structural pavement assessment in Germany

Lutz PINKOFSKY, Dirk JANSEN

Frontiers of Structural and Civil Engineering 2018, Volume 12, Issue 2,   Pages 183-191 doi: 10.1007/s11709-017-0412-z

Abstract: motorways and trunk roads encourages the use of innovative, sound and reliable methods for the structural assessmentEssential elements for this are data, which allow a reliable assessment.For a holistic approach to structural pavement assessment performance orientated measurements will beThe paper summarizes the actual assessment procedures in Germany as well as the ongoing work on the development

Keywords： pavement assessment     Germany     structure     system    

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Environmental and human health impact assessment of major interior wall decorative materials

Bingqing ZHANG, Ruochen ZENG, Xiaodong LI

Frontiers of Engineering Management 2019, Volume 6, Issue 3,   Pages 406-415 doi: 10.1007/s42524-019-0025-4

Abstract: The environmental impact assessment follows life cycle assessment (LCA) methodology and applies BuildingThe assessment scope, associated emissions, and territorial scope of various emissions are defined toAssessment results reveal that the integrated impact of interior latex is lower than that of non-woven

Keywords： life cycle assessment     human health impact     integrated assessment     interior wall decorative material     green    

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SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS

Frontiers of Agricultural Science and Engineering 2022, Volume 9, Issue 3,   Pages 356-365 doi: 10.15302/J-FASE-2022458

Abstract:

● A composite N management index is proposed to measure agriculture sustainability.

Keywords： global assessment     indicator     nitrogen management     sustainable agriculture     sustainable development goals    

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Game theoretic analysis of environmental impact assessment system in China

CHENG Hongguang, PU Xiao, GONG Li, QI Ye

Frontiers of Environmental Science & Engineering 2007, Volume 1, Issue 4,   Pages 448-453 doi: 10.1007/s11783-007-0071-8

Abstract: Environmental impact assessment (EIA) system has been established in China since 1973.

Keywords： public     impact assessment     Environmental impact     general    

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Creep life assessment of aero-engine recuperator based on continuum damage mechanics approach

Frontiers of Mechanical Engineering 2022, Volume 17, Issue 4, doi: 10.1007/s11465-022-0702-6

Abstract: The creep life of an aeroengine recuperator is investigated in terms of continuum damage mechanics by using finite element simulations. The effects of the manifold wall thickness and creep properties of brazing filler metal on the operating life of the recuperator are analyzed. Results show that the crack initiates from the brazing filler metal located on the outer surface of the manifold with the wall thickness of 2 mm and propagates throughout the whole region of the brazing filler metal when the creep time reaches 34900 h. The creep life of the recuperator meets the requirement of 40000 h continuous operation when the wall thickness increases to 3.5 mm, but its total weight increases by 15%. Decreasing the minimum creep strain rate with the enhancement of the creep strength of the brazing filler metal presents an obvious effect on the creep life of the recuperator. At the same stress level, the creep rupture time of the recuperator is enhanced by 13 times if the mismatch between the minimum creep rate of the filler and base metal is reduced by 20%.

Keywords： creep     life assessment     brazed joint     continuum damage mechanics     aeroengine recuperator    

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Fate and risk assessment of emerging contaminants in reclaimed water production processes

Frontiers of Environmental Science & Engineering 2021, Volume 15, Issue 5, doi: 10.1007/s11783-021-1392-8

Abstract:

• PPCPs had the highest removal efficiency in A2O combined with MBR process (86.8%).

Keywords： Trace organic pollution     Antibiotic resistance genes     Reclaimed wastewater     Sludge     Risk assessment    

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design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Frontiers of Medicine 2019, Volume 13, Issue 2,   Pages 277-284 doi: 10.1007/s11684-018-0630-3

Abstract: The development of new proton-pump inhibitors (PPIs) with less adverse effects by lowering the pKa values of nitrogen atoms in pyrimidine rings has been previously suggested by our group. In this work, we proposed that new PPIs should have the following features: (1) number of ring II= number of ring I+ 1; (2) preferably five, six, or seven-membered heteroatomic ring for stability; and (3) 1

Keywords： proton-pump inhibitor     adverse effect     pharmacological mechanism     toxicological mechanism     pKa calculation    

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Environmental, social, and economic assessment of energy utilization of crop residue in China

Yueling ZHANG, Junjie LI, Huan LIU, Guangling ZHAO, Yajun TIAN, Kechang XIE

Frontiers in Energy 2021, Volume 15, Issue 2,   Pages 308-319 doi: 10.1007/s11708-020-0696-x

Abstract: The methodologies employed to achieve this objective are environmental life cycle assessment (E-LCA),life cycle cost (LCC), and social life cycle assessment (S-LCA).

Keywords： crop residue     life cycle assessment     life cycle cost     social life cycle assessment     energy production    

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Lifecycle carbon footprint and cost assessment for coal-to-liquid coupled with carbon capture, storage

Frontiers in Energy 2023, Volume 17, Issue 3,   Pages 412-427 doi: 10.1007/s11708-023-0879-3

Abstract: technology has the potential to reduce CO2 emissions, but its carbon footprint and cost assessment

Keywords： carbon capture     utilization and storage (CCUS)     carbon footprint     levelized cost of liquid     lifecycle assessment    

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Title Author Date Type Operation

Artificial Bear Bile: A Novel Approach to Balancing Medical Requirements and Animal Welfare

Yong Li,Yuhong Huang,Nan Feng,Heping Zhang,Jing Qu,Shuanggang Ma,Yunbao Liu,Jiang Li,Shaofeng Xu,Ling Wang,Mi Zhang,Jie Cai,Weiping Wang,Ru Feng,Hang Yu,Bo Yu,Dailiang Liang,Heping Qin,Suxiang Luo,Yanfen Li,

Journal Article

Two-dimensional numerical and eco-toxicological modeling of chemical spills

Suiliang HUANG, Yafei JIA, Sam S. Y. WANG

Journal Article

The Application and the Developing Direction of Forensic Toxicological Analysis

Liu Yao

Journal Article

human umbilical cord-derived mesenchymal stem cells to differentiate into sweat gland-like cells: a preclinical

Siming Yang, Kui Ma, Changjiang Feng, Yan Wu, Yao Wang, Sha Huang, Xiaobing Fu

Journal Article

non-ligand-blocking agonistic anti-OX40 antibody, exhibits superior immune activation and antitumor effects in preclinical

Journal Article

Patient-derived xenograft platform of OSCC: a renewable human bio-bank for preclinical cancer research

Shuyang Sun,Zhiyuan Zhang

Journal Article

Structural pavement assessment in Germany

Lutz PINKOFSKY, Dirk JANSEN

Journal Article

Environmental and human health impact assessment of major interior wall decorative materials

Bingqing ZHANG, Ruochen ZENG, Xiaodong LI

Journal Article

SUSTAINABLE NITROGEN MANAGEMENT INDEX: DEFINITION, GLOBAL ASSESSMENT AND POTENTIAL IMPROVEMENTS

Journal Article

Game theoretic analysis of environmental impact assessment system in China

CHENG Hongguang, PU Xiao, GONG Li, QI Ye

Journal Article

Creep life assessment of aero-engine recuperator based on continuum damage mechanics approach

Journal Article

Fate and risk assessment of emerging contaminants in reclaimed water production processes

Journal Article

design of novel proton-pump inhibitors with reduced adverse effects

Xiaoyi Li, Hong Kang, Wensheng Liu, Sarita Singhal, Na Jiao, Yong Wang, Lixin Zhu, Ruixin Zhu

Journal Article

Environmental, social, and economic assessment of energy utilization of crop residue in China

Yueling ZHANG, Junjie LI, Huan LIU, Guangling ZHAO, Yajun TIAN, Kechang XIE

Journal Article

Lifecycle carbon footprint and cost assessment for coal-to-liquid coupled with carbon capture, storage

Journal Article